NEWTOWN SQUARE, PA — ArriVent BioPharma, Inc. (Nasdaq: AVBP) has announced positive strides in its first-quarter progress, particularly in the development of firmonertinib, a promising drug for non-small cell lung cancer (NSCLC) patients with specific genetic mutations. The company, under the leadership of Chairman and CEO Bing Yao, is actively advancing its clinical trials and expanding its research portfolio.
During the first quarter ended March 31, 2024, ArriVent fully enrolled the NSCLC EGFR PACC mutation Phase 1b cohort in its FURTHER study. Additionally, it kicked off a Phase 1b combination study of firmonertinib with ICP-189, targeting NSCLC patients with EGFR classical mutations. This marks a significant step in leveraging firmonertinib’s potential across various EGFR mutant NSCLC subtypes.
At the 2024 AACR Annual Meeting, ArriVent presented preclinical data showcasing firmonertinib’s broad activity against uncommon mutations, including PACC and exon 20 insertion mutations. This positions firmonertinib as a highly brain penetrant and mutant-selective EGFR inhibitor.
In collaboration with InnoCare Pharma, ArriVent began dosing patients in the Phase 1b clinical combination study in March 2024, focusing on advanced or metastatic NSCLC patients. This partnership underscores a strategic move to enhance firmonertinib’s clinical application.
Looking ahead, ArriVent expects to announce proof-of-concept data for firmonertinib in 2024. The company is also progressing in its partnership with Aarvik Therapeutics, Inc., aiming to select a next-generation antibody drug conjugate (ADC) development candidate by late 2024 or early 2025.
Financially, ArriVent reported a robust cash position of $317.4 million as of March 31, 2024, anticipated to support its operations well into 2026. Despite increases in research and development expenses and general administrative costs, the company remains poised for significant advancements in cancer treatment.
With the appointment of Kristine Peterson to the Board of Directors, ArriVent strengthens its leadership team, bringing decades of biopharmaceutical expertise to its strategic direction.
ArriVent’s developments reflect a focused effort to address the unmet needs of NSCLC patients through innovative therapies. The company’s ongoing initiatives and financial health signal a promising future in the fight against lung cancer.
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