PHILADELPHIA, PA — VintaBio announced it has filed provisional patents with the U.S. Patent and Trademark Office for a new approach to manufacturing biotherapeutics using adherent culturing methods in small-scale systems. The company says its process, designed to address scalability challenges in gene therapy production, has the potential to shorten development timelines while reducing space and equipment needs by as much as 80 percent.
The method improves on existing adherent manufacturing approaches used for FDA-approved gene therapies such as Zolgensma and Luxturna. VintaBio’s process relies on high-density culturing of adherent cells in single-use benchtop bioreactors, eliminating the need for plastic flasks and other flatware commonly used in the field.
The platform has already demonstrated success in producing AAV viral vector gene therapies with an HEK293 cell line. According to the company, batch data showed more than 60 percent full capsids at harvest, with final purification exceeding 95 percent. Overall process recovery was about 60 percent. Proof-of-concept work is underway for other viral vectors including lentivirus, adenovirus, and HSV.
VintaBio’s founders, who previously contributed to several FDA-approved gene therapy programs, designed the system to overcome the productivity and scalability limits of adherent culture. The process is also being evaluated for use in vaccines and other biotherapeutics.
“The growing interest in our platform is a strong indication that the industry is keen to find better ways to get critical therapies to patients,” said David Radspinner, PhD, CEO of VintaBio. “Our recent scientific and commercial accomplishments have us poised to take on these challenges and continue to generate strong market demand for other applications.”
By reducing reliance on large operational footprints, the process enables faster scaling and more efficient global deployment. VintaBio estimates the development timeline for biotherapeutics could be cut from 18 months to as little as three to six months.
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