CONSHOHOCKEN, PA — Tiger BioSciences is spotlighting new scientific momentum behind its placental-derived allograft technologies, citing a peer-reviewed study that compares 2-, 3-, and 4-layer membrane constructs and spotlights how structural differences influence biochemical performance. The findings, published in the International Journal of Molecular Sciences, continue to shape research and development within the growing field of Cellular Acellular and Matrix-like Products (CAMPs).
The human placenta has become a pivotal material in modern wound care due to its extracellular matrix, collagen density, and growth-factor profile. Tiger BioSciences produces allografts in multiple configurations, including two-layer amnion, full-thickness membranes containing the amnion, intermediate layer, and chorion, and a four-layer construct that adds an additional amnion layer for increased biological complexity.
The study found that all three constructs retained key characteristics of placental tissue, but also revealed meaningful differences. Collagen levels in the four-layer configuration were roughly double those found in the two- and three-layer products. ECM components — including elastin, proteoglycans, and hyaluronic acid — were more abundant in both the three- and four-layer grafts. Growth factors such as ANG-2, EGF, PDGF-AA, and VEGF were present across all samples, with higher retention in the thicker constructs.
Garrett Grinsfelder, president of Tiger Wound Care, said the data illustrates the importance of structural preservation and confirms the biological strength of multi-layer technologies. He said the research reinforces the company’s efforts to engineer allografts that mirror the complexity of native placental tissue.
As clinicians look for more effective solutions for chronic and acute wounds, the company sees multi-layer placental allografts as a scientifically validated option supported by increasing clinical interest. Tiger BioSciences said the study adds to a growing body of evidence guiding the next generation of tissue-based wound-care products.
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