WILMINGTON, DE — AstraZeneca plc (Nasdaq: AZN) is sharply expanding its ambitions in hematology and cell therapy, unveiling new clinical data across blood cancers as it makes its largest-ever showing at the American Society of Hematology annual meeting.
The drugmaker said it will present 65 abstracts at the Dec. 6–9 conference, spanning eight approved and investigational medicines, including 15 oral presentations. The scale of the presence reflects AstraZeneca’s growing investment in blood cancers, rare hematologic disorders, and next-generation cell therapies.
Among the most closely watched data are early results for surovatamig, an investigational CD19xCD3 T-cell engager, and AZD0120, the company’s first chimeric antigen receptor T-cell therapy. Initial findings suggest potential activity across multiple malignancies, including relapsed or refractory multiple myeloma and B-cell cancers, areas of intense competition across the biopharmaceutical industry.
AstraZeneca is also highlighting longer-term and late-stage data for established therapies. New analyses will detail extended follow-up results for CALQUENCE in mantle cell lymphoma and chronic lymphocytic leukemia, as well as additional Phase III data for ULTOMIRIS in paroxysmal nocturnal hemoglobinuria. The company said new findings will also explore ULTOMIRIS’ potential to improve outcomes in pediatric patients with stem cell transplant-associated thrombotic microangiopathy.
Senior executives framed the breadth of data as evidence of a maturing pipeline capable of reshaping treatment standards. Company leaders said the focus extends beyond oncology to rare, life-threatening blood disorders, particularly through the integration of Alexion, AstraZeneca’s rare disease unit.
The company’s growing footprint at ASH reflects a broader strategic push. In recent years, AstraZeneca has invested heavily in cell therapy capabilities and advanced immunology platforms, aiming to compete with both large pharmaceutical rivals and specialized biotech firms racing to define the next wave of blood cancer treatments.
For investors and clinicians alike, the meeting offers a high-stakes look at whether AstraZeneca’s expanding portfolio can translate early promise into durable clinical and commercial success, as the company seeks to position hematology and cell therapy as a central growth engine in its long-term strategy.
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