WILMINGTON, DE — AstraZeneca has announced a sweeping $50 billion investment across the United States through 2030, marking the company’s largest commitment to U.S. pharmaceutical operations to date. The move signals a major vote of confidence in America’s role as a global hub for drug innovation, manufacturing, and biopharma job creation.
At the heart of the plan is a new multi-billion-dollar manufacturing facility in Virginia that will produce active pharmaceutical ingredients for AstraZeneca’s expanding portfolio of metabolic and weight management medicines. The plant will focus on next-generation small molecules, peptides, and oligonucleotides, including candidates such as oral GLP-1 therapies, baxdrostat, and oral PCSK9 inhibitors. Once complete, it will be the company’s single largest manufacturing investment worldwide.
AstraZeneca said the facility will feature advanced technologies including artificial intelligence, robotics, and predictive analytics to streamline production. The site is expected to generate hundreds of highly skilled jobs while reinforcing domestic supply chains for critical medicines.
“This historic investment is bringing tens of thousands of jobs to the U.S. and will ensure medicine sold in our country is produced right here,” said U.S. Secretary of Commerce Howard Lutnick, linking the investment to broader national efforts to bolster domestic drug production and reduce reliance on foreign suppliers.
Virginia Governor Glenn Youngkin welcomed the decision to site the facility in the Commonwealth, calling it “a transformational investment” and noting the economic impact of expanding advanced pharmaceutical manufacturing in the state.
Beyond Virginia, the company is also investing heavily in research and development across the country. Key projects include:
- Expansion of the Gaithersburg, Maryland R&D facility
- A new R&D center in Cambridge, Massachusetts
- Cell therapy manufacturing in Rockville, Maryland, and Tarzana, California
- Advanced production upgrades in Mount Vernon, Indiana, and Coppell, Texas
- New sites to support clinical trials
These efforts align with AstraZeneca’s broader strategic goal to launch 20 new medicines and reach $80 billion in total revenue by the end of the decade. The company expects half of that figure to come from its U.S. operations, which already account for 42% of revenue.
CEO Pascal Soriot underscored the company’s long-term view: “Today’s announcement underpins our belief in America’s innovation in biopharmaceuticals and our commitment to the millions of patients who need our medicines in America and globally.”
AstraZeneca currently employs more than 18,000 people across 19 U.S. locations and supports a total of 92,000 jobs nationwide. In 2024, the company contributed $5 billion directly to the U.S. economy, with an estimated total impact of $20 billion.
With the new investments, AstraZeneca aims to deepen its footprint in the U.S. while accelerating access to innovative treatments and strengthening domestic manufacturing capacity—an issue that has taken on renewed urgency in the wake of recent global supply chain disruptions.
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