WASHINGTON, D.C. — President Donald Trump on Monday unveiled an ambitious national effort to accelerate scientific research through artificial intelligence, launching what the White House calls the “Genesis Mission,” a sweeping initiative that officials describe as one of the most significant U.S. scientific mobilizations since the Manhattan Project.
Signed in a new Executive Order, the plan directs the Department of Energy to build an integrated AI-powered research platform that combines the federal government’s vast scientific datasets, national laboratory supercomputers, and emerging AI technologies into a single system designed to speed discovery across fields ranging from biotechnology to nuclear fusion.
The order tasks Energy Secretary leadership with establishing and operating the “American Science and Security Platform,” a secure, closed-loop AI environment that will train scientific foundation models, power robotic laboratories, automate research workflows, and analyze experimental data at unprecedented scale. Within months, the agency must map existing high-performance computing resources, identify priority datasets, and demonstrate early capabilities targeted at national science and technology challenges.
White House officials say the effort will allow scientists to test hypotheses, simulate complex systems, and design experiments far faster than current traditional methods. Proponents inside the administration argue that research once requiring years could be completed in weeks or months.
The initiative assigns the Assistant to the President for Science and Technology to coordinate the program across federal agencies, with collaboration from the Special Advisor for AI and Crypto. The effort calls for partnerships with universities, private-sector companies, and international scientific organizations, provided they meet strict cybersecurity and data-security requirements.
A fact sheet from the White House frames the mission as a response to lagging scientific productivity despite steady increases in federal research spending since the 1990s. Administration officials contend that harnessing AI to interpret and generate data will reverse that trend by dramatically expanding federal research capacity.
The Executive Order outlines a series of deadlines directing the Department of Energy to identify at least 20 high-priority scientific challenges within 60 days, including work in quantum information science, semiconductors, advanced manufacturing, critical materials, and nuclear fission and fusion. Those challenges would form the basis of cross-agency research projects supported by the new platform.
The White House emphasized that the program is part of a broader effort by the Trump Administration to strengthen U.S. leadership in artificial intelligence. Officials pointed to earlier executive actions aimed at reversing previous federal AI policies, promoting AI education, and expanding the development and export of American AI technologies.
“The Genesis Mission connects world-class scientific data with the most advanced American AI to unlock breakthroughs in medicine, energy, materials science, and beyond,” said Michael Kratsios, Assistant to the President for Science and Technology.
Annual public reports will detail progress on the platform’s capabilities, scientific outputs, partnerships, and any recommendations for broader federal support.
The Executive Order, the latest in a series of administration efforts to reshape national AI strategy, positions AI not just as a technological priority but as a central tool for U.S. economic competitiveness and national security in the decades ahead.
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