Zynerba Pharmaceuticals Presents Long-Term Safety and Efficacy Data of Zygel in Children and Adolescents

Zynerba Pharmaceuticals

DEVON, PA — Zynerba Pharmaceuticals, Inc. (Nasdaq: ZYNE) this week presented an oral podium presentation at the International Society for Autism Research Annual Meeting (INSAR 2022). A copy of the presentation is available on the Zynerba corporate website at https://www.zynerba.com/publications/.

The presentation titled, “Long-Term Safety and Sustained Efficacy of ZYN002 Cannabidiol Transdermal Gel in Children and Adolescents with Fragile X Syndrome (ZYN2-CL-017),” included data from 240 patients and demonstrates the long-term safety and efficacy of Zygel in children and adolescents with FXS.

The study includes patients who entered the trial from two completed trials with Zygel: CONNECT-FX, a randomized, double-blind, placebo-controlled Phase 3 trial, and FAB-C, the initial open-label Phase 2 trial in FXS. The efficacy data were evaluated through 15 months of treatment and demonstrated improvements in both ABC-CFXS Social Avoidance and Irritability subscales. Patients with complete methylation of their FMR1 gene who completed CONNECT-FX and matched the primary efficacy population in the ongoing confirmatory RECONNECT trial achieved and maintained clinically meaningful change in ABC-CFXS Social Avoidance, and demonstrated similar improvements in ABC-CFXS Irritability subscale scores. These finding support the design enhancements that were made for RECONNECT.

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Zygel was well tolerated in patients, with a median duration of exposure of 16 months (range 21 days to 38 months). Adverse events potentially related to Zygel were reported in 12.9% of patients; the most common reported in 6.7% of patients was application site pain which resolved quickly and was mild in the majority of cases.

“The interim results from this open-label extension trial support the long-term safety and effectiveness of Zygel in children and adolescents with Fragile X syndrome, with the greatest improvements seen in those with complete methylation of their FMR1 gene,” said Armando Anido, Chairman and Chief Executive Officer of Zynerba. “We are excited by the potential that Zygel may offer for patients with FXS.”

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