WAYNE, PA — Teleflex Incorporated (NYSE: TFX) announced that new data published in the peer-reviewed journal, European Urology Focus, found that men treated with the Prostatic Urethral Lift (PUL) procedure (using the UroLift® System) showed preservation and some improvement of sexual function compared to men being treated with medication for benign prostatic hyperplasia (BPH).
The comparative analysis “Prostatic Urethral Lift vs. Medical Therapy: Examining the Impact on Sexual Function in Men with BPH,” is the first study to longitudinally compare sexual function outcomes between major PUL studies1-4 and data from the Medical Therapy of Prostatic Symptoms (MTOPS) trial. Treatment-related changes in sexual function were reported by validated patient questionnaires. In this comparison, researchers demonstrated that the UroLift System procedure maintained sexual function among sexually active men in all three domains (erectile function, ejaculatory function, and sexual satisfaction) that were examined, and even improved sexual function at certain timepoints. This was in contrast to daily treatment with an alpha blocker (doxazosin), 5-alpha-reductase inhibitor (finasteride), either alone or in combination with each other. This study was sponsored by Teleflex Incorporated.
“Within this comparative analysis examining the impact of PUL or medical therapy on male sexual health, we challenge the idea that medical therapy is the most conservative minimally invasive treatment option for BPH patients,” said Claus G. Roehrborn+, M.D., Urologist at the University of Texas Southwestern Medical Center and a lead author on the paper. “The results show that the sexual health preservation benefits provided by the UroLift System were not seen with medication. The UroLift System can provide rapid relief for the symptoms of BPH while sustaining and sometimes even improving sexual function.”
Mean percent changes in erectile function, ejaculatory function, and sexual satisfaction from patient reported questionnaires were analyzed to determine improvements in sexual function. Key findings include:
- Following the UroLift System procedure, patients experienced a significant improvement in erectile function (17% at 1 year and 21% at 2 years). PUL was shown to be superior at preserving erectile function compared to medical therapy, specifically: doxazosin at 1 and 2 years, finasteride at 2 and 4 years, and combination therapy at 1 year.
- Men who received the UroLift System also experienced significant improvements in ejaculatory function over 4 years, with mean percentage changes from baseline in ejaculatory function score reaching 35%, 33%, 14%, and 18% at 1, 2, 3, and 4 years respectively. Conversely, men treated with finasteride or combination therapy experienced a decline in ejaculatory function. Among the drug therapy groups, combination therapy resulted in the greatest decrease in ejaculatory function, leading to a statistically significant reduction in the mean ejaculatory function score relative to baseline at 1 and 2 years of 17% and 13% respectively.
- Sexual satisfaction scores among patients treated with the UroLift System increased 22%, 21%, 19%, and 28% at 1, 2, 3, and 4 years respectively. In contrast, subjects treated with doxazosin, finasteride, or combination therapy experienced an overall decrease in sexual satisfaction during follow-up, however differences in mean percentage change from baseline were not statistically significant.
“This is an important study that highlights the unique benefits of the UroLift System in preserving sexual function in BPH patients,” said Tyler Binney, president of Teleflex Interventional Urology business unit. “In terms of sexual function, the UroLift System outperformed medications that are prescribed for BPH. These results indicate physicians can confidently recommend the UroLift System as a treatment option that can improve their patient’s quality of life, particularly in terms of sexual function and satisfaction.”
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