Annovis Bio Submits International Patent Application

Annovis Bio

BERWYN, PA — Annovis Bio (NYSE: ANVS) recently announced that the company submitted an international patent application under the Patent Cooperation Treaty for its drug platform buntanetap. The patent claims a method of inhibiting, preventing, or treating neurological injuries due to viral, bacterial, fungal, protozoan, or parasitic infections in humans.

If granted, the patent application will add to the intellectual property of the Company whose issued patents to date cover a wide range of neurodegenerative diseases, including Alzheimer’s disease (AD), alpha-synucleopathies, such as Parkinson’s disease (PD), tauopathies, such as frontotemporal dementia (FTD) and chronic traumatic encephalopathy (CTE) and acute injuries such as stroke and traumatic brain injury. Neurotoxic protein levels, such as APP/Abeta, alpha-synuclein and tau/phospho-tau, are high in both chronic and acute brain injuries. Because infections, whether viral, bacterial, or fungal, also cause an increase in these neurotoxic proteins, buntanetap has the potential to protect the brain from damage caused by infections. Data included in the filed patent demonstrates that buntanetap lowers the levels of these neurotoxic proteins protects astroglia from gingipains and restores normal morphology and function to nerve cells. If granted, the patent could provide intellectual property protection through 2042.

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“This new patent application is not only another step in strengthening the Company’s position and expanding its intellectual property portfolio but is also additional proof that consolidates our platform. Simply put, the Annovis story and potential are much broader than AD and PD. Because of its unique mode of action, our drug has the potential to act on a variety of neurodegenerative disorders,” said Maria L. Maccecchini, Ph.D., Founder, President, and CEO of Annovis.

“All indications for which we are testing buntanetap have a shared basic mechanism: certain proteins are overexpressed, become neurotoxic and trigger a cascade that slows axonal transport, increases inflammation, reduces the viability and function of neurons, and ultimately causes loss of function. Our drug reverses this toxic cascade by selectively inhibiting the translation of these neurotoxic proteins that are at play in these debilitating diseases and, therefore, restores the affected function,” Dr. Maccecchini added.

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Currently, Annovis is advancing buntanetap for the treatment of AD and PD and expects to start recruitment for a Phase 3 clinical trial in early PD patients this summer.

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